Treating prolactinomas with dopamine agonists: always worth the gamble?

Endocrine. 2016 Feb;51(2):205-10. doi: 10.1007/s12020-015-0727-2. Epub 2015 Sep 4.

Abstract

Dopamine agonists are the treatment of choice for all patients with prolactinomas. They are generally safe, effective, and well-tolerated. However, a link between their use and the development of impulse control disorders has been well recognized in the field of neurology for some time, and evidence for a similar effect in endocrine patients is emerging. This has mainly been revealed through clinical case reports, plus a small number of comparative studies of varying robustness. We review the current available literature and discuss the implications for clinical practice, in particular emphasizing the need for clinicians to be alert to these uncommon but serious adverse effects.

Keywords: Bromocriptine; Cabergoline; Gambling; Hypersexuality; Impulse control.

Publication types

  • Review

MeSH terms

  • Disruptive, Impulse Control, and Conduct Disorders / chemically induced*
  • Dopamine Agonists / adverse effects
  • Dopamine Agonists / therapeutic use*
  • Humans
  • Pituitary Neoplasms / drug therapy*
  • Prolactinoma / drug therapy*
  • Treatment Outcome

Substances

  • Dopamine Agonists