Promise of cancer stem cell vaccine

Hum Vaccin Immunother. 2015;11(12):2796-9. doi: 10.1080/21645515.2015.1083661.

Abstract

Dendritic cell (DC)-based vaccines designed to target cancer stem cells (CSC) can induce significant antitumor responses via conferring host anti-CSC immunity. Our recent studies have demonstrated that CSC-DC vaccine could inhibit metastasis of primary tumors and induce humoral immune responses against cancer stem cells. This approach highlights the promise of cancer stem cell vaccine in cancer immunotherapy.

Keywords: cancer stem cell (CSC); dendritic cells (DC); programmed death-1 (PD-1); vaccine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Neoplasm / immunology
  • Cancer Vaccines / therapeutic use*
  • Dendritic Cells / immunology*
  • Dendritic Cells / transplantation*
  • Humans
  • Immunotherapy, Adoptive / methods*
  • Mice
  • Neoplasm Metastasis / prevention & control
  • Neoplasms / therapy*
  • Neoplastic Stem Cells / immunology*

Substances

  • Antigens, Neoplasm
  • Cancer Vaccines