Abstract
Several alkyl and arylalkyl diethylphosphonates related to fostedil have been synthetized and tested for negative inotropic activity (isolated guinea pig left atrium) and Ca++ antagonistic activity (isolated guinea pig aortic strips). The results show that negative inotropic and Ca++ antagonistic activity might depend from different molecular features.
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Calcium Channel Blockers / chemical synthesis
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Calcium Channel Blockers / pharmacology*
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Chemical Phenomena
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Chemistry
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Female
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Guinea Pigs
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In Vitro Techniques
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Male
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Muscle, Smooth, Vascular / drug effects
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Myocardial Contraction / drug effects*
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Organophosphorus Compounds / chemical synthesis
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Organophosphorus Compounds / pharmacology*
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Potassium Chloride / pharmacology
Substances
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Calcium Channel Blockers
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Organophosphorus Compounds
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Potassium Chloride