Synthesis and biological activity of a cyclic hexapeptide related to peptide T

Farmaco. 1989 Dec;44(12):1233-7.

Abstract

The cyclo [Thr-Thr-Thr-Tyr-Asn-Thr] hexapeptide related to peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, competitor of the Human Immunodeficiency Virus in the binding to human T cells, was synthesized and tested for its ability to stimulate monocyte migration (chemotaxis). The new cyclic derivative showed negligible biological activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Chemical Phenomena
  • Chemistry
  • Chemotaxis, Leukocyte / drug effects
  • Humans
  • In Vitro Techniques
  • Molecular Sequence Data
  • Monocytes / drug effects
  • Peptide T / analogs & derivatives
  • Peptide T / chemical synthesis*
  • Peptide T / pharmacology

Substances

  • Peptide T