Iridium-Catalyzed Enantioselective Fluorination of Racemic, Secondary Allylic Trichloroacetimidates

J Am Chem Soc. 2015 Sep 23;137(37):11912-5. doi: 10.1021/jacs.5b07492. Epub 2015 Sep 10.

Abstract

The Ir-catalyzed enantioselective fluorination of racemic, branched allylic trichloroacetimidates with Et3N·3HF is a mild and efficient route for selective incorporation of fluoride ion into allylic systems. We herein describe the asymmetric fluorination of racemic, secondary allylic electrophiles with Et3N·3HF using a chiral-diene-ligated Ir complex. The methodology enables the formation of acyclic fluorine-containing compounds in good yields with excellent levels of asymmetric induction and overcomes the limitations previously associated with the enantioselective construction of secondary allylic fluorides bearing α-linear substituents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / chemistry*
  • Catalysis
  • Chloroacetates / chemistry*
  • Halogenation*
  • Iridium / chemistry*
  • Models, Molecular
  • Molecular Conformation
  • Stereoisomerism

Substances

  • Acetamides
  • Chloroacetates
  • Iridium
  • trichloroacetamide