RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

J Antibiot (Tokyo). 2016 Feb;69(2):121-3. doi: 10.1038/ja.2015.94. Epub 2015 Sep 9.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Enzyme Inhibitors / pharmacology*
  • Fatty Alcohols / pharmacology*
  • Human Umbilical Vein Endothelial Cells / drug effects*
  • Human Umbilical Vein Endothelial Cells / physiology*
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Neovascularization, Physiologic / drug effects*
  • Phosphoproteins / antagonists & inhibitors*
  • Pyrans / pharmacology*
  • RNA Splicing Factors
  • Ribonucleoprotein, U2 Small Nuclear / antagonists & inhibitors*
  • Spliceosomes / drug effects*

Substances

  • Enzyme Inhibitors
  • Fatty Alcohols
  • Phosphoproteins
  • Pyrans
  • RNA Splicing Factors
  • Ribonucleoprotein, U2 Small Nuclear
  • SF3B1 protein, human
  • herboxidiene