Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing

Benjamin A Diner; Ileana M Cristea

doi:10.1016/j.chom.2015.08.012

Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing

Cell Host Microbe. 2015 Sep 9;18(3):270-2. doi: 10.1016/j.chom.2015.08.012.

Authors

Benjamin A Diner¹, Ileana M Cristea²

Affiliations

¹ Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA.
² Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA. Electronic address: [email protected].

Abstract

Detection of viral DNA is essential for eliciting mammalian innate immunity. However, viruses have acquired effective mechanisms for blocking host defense. Indeed, in this issue of Cell Host & Microbe, Wu et al. (2015) discover a herpesviral strategy for inhibiting the prominent host sensor of viral DNA, cGAS.

Publication types

Comment

MeSH terms

DNA, Viral / metabolism*
Herpesvirus 8, Human / physiology*
Host-Pathogen Interactions*
Humans
Immune Evasion*
Nucleotidyltransferases / antagonists & inhibitors*
Nucleotidyltransferases / metabolism*
Viral Proteins / metabolism*

Substances

DNA, Viral
Viral Proteins
Nucleotidyltransferases

Abstract

Publication types

MeSH terms

Substances

Grants and funding