[Eosinophilic pleuritic: An unusual complication of treatment with an angiotensin converting enzyme inhibitor]

Rev Mal Respir. 2015 Sep;32(7):737-41. doi: 10.1016/j.rmr.2014.08.004. Epub 2014 Sep 11.
[Article in French]

Abstract

Background: Eosinophilic pleural effusions are defined by an eosinophil count ≥10% in pleural fluid and represent approximately 10% of exudative pleural effusions.

Observation: We report the first case of eosinophilic pleural effusion occurring due to lisinopril treatment. Improvement after drug discontinuation and recurrence after reintroduction indicated that lisinopril was responsible for the effusion.

Conclusion: The main causes of eosinophilic pleural effusions are infections including tuberculosis, and malignancies. Drug-induced eosinophilic pleural effusions have only rarely been described, mainly caused by cardiovascular or neuropsychiatric medicines.

Keywords: Angiotensin converting enzyme inhibitor; Eosinophilic pleural effusion; Iatrogenic pleural effusion; Inhibiteur de l’enzyme de conversion de l’angiotensine; Lisinopril; Pleural fluid; Pleurésie iatrogène; Pleurésie à éosinophile; Épanchement pleural.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / adverse effects*
  • Eosinophilia / chemically induced*
  • Eosinophilia / complications
  • Female
  • Humans
  • Hypertension / drug therapy
  • Lisinopril / adverse effects*
  • Middle Aged
  • Pleural Effusion / chemically induced
  • Pleural Effusion / complications
  • Pleurisy / chemically induced*
  • Pleurisy / complications

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Lisinopril