Abstract
Secondary mitral regurgitation (MR) has a complex pathophysiology that includes global or segmental left ventricular (LV) motion abnormalities (of non-ischaemic or ischaemic origin) leading to impaired leaflet coaptation of a normally structured mitral valve (MV). In this context, the LV functional and geometrical changes result in MV leaflet tethering, MV annulus flattening and the decrement of systolic MV closing forces. In light of its complexity, management of secondary MR remains a challenge. In fact, a long-lasting successful treatment using a single medical device and/or intervention that addresses solely the MV target cannot, at least at the present time, be proposed.
MeSH terms
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Algorithms
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Cardiac Catheterization / adverse effects
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Cardiac Catheterization / instrumentation
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Cardiac Catheterization / methods*
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Critical Pathways
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Heart Valve Prosthesis Implantation / adverse effects
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Heart Valve Prosthesis Implantation / instrumentation
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Heart Valve Prosthesis Implantation / methods*
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Hemodynamics
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Humans
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Mitral Valve Annuloplasty / adverse effects
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Mitral Valve Annuloplasty / instrumentation
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Mitral Valve Annuloplasty / methods*
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Mitral Valve Insufficiency / diagnosis
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Mitral Valve Insufficiency / etiology
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Mitral Valve Insufficiency / physiopathology
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Mitral Valve Insufficiency / therapy*
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Mitral Valve* / physiopathology
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Patient Selection
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Prosthesis Design
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Recovery of Function
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Risk Factors
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Treatment Outcome
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Ventricular Dysfunction, Left / complications
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Ventricular Dysfunction, Left / diagnosis
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Ventricular Dysfunction, Left / physiopathology
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Ventricular Dysfunction, Left / therapy*
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Ventricular Function, Left