Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions

Ashley N Powers; Rahul Satija

doi:10.1186/s13059-015-0778-y

Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions

Genome Biol. 2015 Sep 21;16(1):199. doi: 10.1186/s13059-015-0778-y.

Authors

Ashley N Powers^{1

2}, Rahul Satija^{1

2}

Affiliations

¹ New York Genome Center, New York, NY, 10012, USA. [email protected].
² New York University, Center for Genomics and Systems Biology, New York, NY, 10012, USA. [email protected].

Abstract

Cell-cycle fluctuations drive significant transcriptomic heterogeneity in murine hematopoietic stem cells. Additionally, deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice.

MeSH terms

Animals
Carrier Proteins / genetics*
Cell Differentiation / genetics*
Cell Lineage / genetics
DNA-Binding Proteins
Hematopoietic Stem Cells / cytology
Hematopoietic Stem Cells / metabolism*
High-Throughput Nucleotide Sequencing
Mice
Nuclear Proteins / genetics*
Repressor Proteins
Signal Transduction
Single-Cell Analysis*
Thrombopoiesis / genetics

Substances

Bcl11a protein, mouse
Carrier Proteins
DNA-Binding Proteins
Nuclear Proteins
Repressor Proteins