Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Affiliations

• ¹ Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
• ² Medical College, Xiamen University, Xiamen 361102, China.
• ³ Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
• ⁴ Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
• ⁵ Bioinformatics Service, Norris Medical Library, University of Southern California, Los Angeles, California 90033, USA.
• ⁶ Departments of Pathology and Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.
• ⁷ Department for Health Evidence, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
• ⁸ Comprehensive Cancer Center, The Netherlands, PO Box 19079, 3501 DB Utrecht, The Netherlands.
• ⁹ Department of Epidemiology, Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California 92697, USA.
• ¹⁰ Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., 223040 Minsk, Belarus.
• ¹¹ Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA.
• ¹² Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA.
• ¹³ Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon 97239, USA.
• ¹⁴ Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
• ¹⁵ Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710, USA.
• ¹⁶ Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• ¹⁷ Department of Gynecology and Obstetrics, Haukeland University Hospital, N-5058 Bergen, Norway.
• ¹⁸ Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.
• ¹⁹ Gynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany.
• ²⁰ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Maryland, 20892, USA.
• ²¹ Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3.
• ²² Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
• ²³ Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
• ²⁴ Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, 00100 Helsinki, Finland.
• ²⁵ Department of Pathology, Helsinki University Central Hospital, FI-00014 Helsinki, Finland.
• ²⁶ Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.
• ²⁷ Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia.
• ²⁸ Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia.
• ²⁹ Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK.
• ³⁰ German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
• ³¹ Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
• ³² Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida 33612, USA.
• ³³ Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA.
• ³⁴ Harvard School of Public Health, Boston, Massachusetts 02215, USA.
• ³⁵ Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA.
• ³⁶ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
• ³⁷ Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
• ³⁸ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
• ³⁹ Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756, USA.
• ⁴⁰ Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, 45136 Essen, Germany.
• ⁴¹ Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden, 65199 Wiesbaden, Germany.
• ⁴² Department of Gynecology, Jena University Hospital-Friedrich Schiller University, 07737 Jena, Germany.
• ⁴³ Faculty of Medicine, University of Southampton, Southampton SO16 5YA, UK.
• ⁴⁴ Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
• ⁴⁵ Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, USA.
• ⁴⁶ University Hospital Erlangen, Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany.
• ⁴⁷ Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles California 90095, USA.
• ⁴⁸ Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA.
• ⁴⁹ Shanghai Cancer Institute, Shanghai 200030, China.
• ⁵⁰ Department of Women's Cancer, Institute for Women's Health, University College London, London W1T 7DN, UK.
• ⁵¹ Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
• ⁵² Department of Health Science Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
• ⁵³ Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
• ⁵⁴ Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
• ⁵⁵ Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia.
• ⁵⁶ Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
• ⁵⁷ Departments of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany.
• ⁵⁸ Institute of Cancer Epidemiology, Danish Cancer Society, DK-2100 Copenhagen, Denmark.
• ⁵⁹ Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, 1165 Copenhagen, Denmark.
• ⁶⁰ Gyn Clinic, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
• ⁶¹ Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-0021, Japan.
• ⁶² Department of Statistical Science, Duke University, Durham, North Carolina 27708, USA.
• ⁶³ Department of Gynecology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
• ⁶⁴ Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
• ⁶⁵ Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
• ⁶⁶ Department of Gynaecology, The Juliane Marie Centre, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
• ⁶⁷ Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina 29435, USA.
• ⁶⁸ Radboud University Medical Mentre, Radboud Institute for Health Sciences, 6500 HB Nijmegen, The Netherlands.
• ⁶⁹ Vesalius Research Center, VIB, 3000 Leuven, Belgium.
• ⁷⁰ Laboratory for Translational Genetics, Department of Oncology, University of Leuven, B-3000 Leuven, Belgium.
• ⁷¹ Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, B-3000 Leuven, Belgium.
• ⁷² Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3.
• ⁷³ Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
• ⁷⁴ College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas 77004, USA.
• ⁷⁵ Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
• ⁷⁶ Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
• ⁷⁷ Department of Gynaecology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
• ⁷⁸ Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, 819-0395 Fukuoka, Japan.
• ⁷⁹ Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
• ⁸⁰ Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
• ⁸¹ Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, University of Glasgow, Glasgow G61 1QH, UK.
• ⁸² Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA.
• ⁸³ Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA.
• ⁸⁴ Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10017, USA.
• ⁸⁵ Department of Pathology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
• ⁸⁶ The University of Texas School of Public Health, Houston, Texas 77030, USA.
• ⁸⁷ Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, 50603 Kuala Lumpur, Malaysia.
• ⁸⁸ Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
• ⁸⁹ Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
• ⁹⁰ Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
• ⁹¹ Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA.
• ⁹² Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02215, USA.
• ⁹³ Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut 06510, USA.
• ⁹⁴ Department of Gynecologic-Oncology, Princess Margaret Hospital, and Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 2J7.
• ⁹⁵ Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
• ⁹⁶ Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA.
• ⁹⁷ Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina 27710, USA.
• ⁹⁸ Institut für Humangenetik Wiesbaden, 65187 Wiesbaden, Germany.
• ⁹⁹ Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
• ¹⁰⁰ Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, 96813, USA.
• ¹⁰¹ Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow G4 0SF, UK.
• ¹⁰² University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, 50603 Kuala Lumpur, Malaysia.
• ¹⁰³ Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
• ¹⁰⁴ Department of Obstetrics and Gynecology, University of Ulm, 89075 Ulm, Germany.
• ¹⁰⁵ Cancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center &Research Institute, Tampa, Florida 33612, USA.