Role of Semen on Vaginal HIV-1 Transmission and Maraviroc Protection

Antimicrob Agents Chemother. 2015 Dec;59(12):7847-51. doi: 10.1128/AAC.01496-15. Epub 2015 Sep 21.

Abstract

We used bone marrow/liver/thymus (BLT) humanized mice to establish the effect of semen on vaginal HIV infection and on the efficacy of topically applied maraviroc. Our results demonstrate that vaginal transmission of cell-free HIV occurs efficiently in the presence of semen and that topically applied maraviroc efficiently prevents HIV transmission in the presence of semen. We also show that semen has no significant effect on the transmission of transmitted/founder viruses or cell-associated viruses.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Administration, Intravaginal
  • Animals
  • Anti-HIV Agents / pharmacology*
  • CD4-Positive T-Lymphocytes / drug effects
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / virology
  • Cyclohexanes / pharmacology*
  • Disease Models, Animal
  • Female
  • HIV Infections / immunology
  • HIV Infections / prevention & control*
  • HIV Infections / transmission
  • HIV Infections / virology
  • HIV-1 / drug effects*
  • HIV-1 / physiology
  • Humans
  • Male
  • Maraviroc
  • Mice
  • Mice, Transgenic
  • Semen / drug effects*
  • Semen / virology
  • Triazoles / pharmacology*
  • Vagina / drug effects*
  • Vagina / immunology
  • Vagina / virology
  • Viral Load / drug effects

Substances

  • Anti-HIV Agents
  • Cyclohexanes
  • Triazoles
  • Maraviroc