Abstract
Coadministration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study with 11 HIV-infected adults who were receiving artemether-lumefantrine plus nevirapine-based ART, and we compared the results with those for 16 HIV-negative adult historical controls. Exposure to artemether and lumefantrine was significantly lower and dihydroartemisinin exposure was unchanged in subjects receiving nevirapine-based ART, compared with controls. Nevirapine exposure was unchanged before and after artemether-lumefantrine administration.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-HIV Agents / therapeutic use*
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Antimalarials / blood
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Antimalarials / pharmacokinetics*
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Antimalarials / pharmacology
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Artemether
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Artemisinins / blood
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Artemisinins / pharmacokinetics*
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Artemisinins / pharmacology
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Case-Control Studies
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Coinfection
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Drug Combinations
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Drug Interactions
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Ethanolamines / blood
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Ethanolamines / pharmacokinetics*
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Ethanolamines / pharmacology
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Female
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Fluorenes / blood
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Fluorenes / pharmacokinetics*
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Fluorenes / pharmacology
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HIV Infections / drug therapy*
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HIV Infections / virology
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HIV-1 / drug effects
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HIV-1 / physiology
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Humans
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Lumefantrine
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Malaria, Falciparum / drug therapy
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Malaria, Falciparum / parasitology
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Male
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Nevirapine / therapeutic use*
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Nigeria
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Plasmodium falciparum / drug effects
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Plasmodium falciparum / physiology
Substances
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Anti-HIV Agents
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Antimalarials
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Artemisinins
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Drug Combinations
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Ethanolamines
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Fluorenes
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artenimol
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Nevirapine
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Artemether
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Lumefantrine