We have reported that TLR5-mediated recognition of commensal microbiota modulates systemic tumor-promoting inflammation and malignant progression of tumors at distal locations. Approximately 7-10% of the general population harbors a deleterious single nucleotide polymorphism in TLR5, implicating a novel role for genetic variation during the initiation and progression of cancer.
Keywords: cancer; inflammation; microbiota; toll-like receptor; tumor immunology; tumor macroenvironment; tumor microenvironment; tumor-induced immune suppression.