Intussusception Cases Among Children Admitted to Referral Hospitals in Kenya, 2002-2013: Implications for Monitoring Postlicensure Safety of Rotavirus Vaccines in Africa

Richard Omore; Francis Osawa; Janet Musia; Brian Rha; Amina Ismail; Nicholas Mukaria Kiulia; Fenny Moke; John Vulule; Anthony Mungai Wainaina; John Tole; Stanley Mugambi Machoki; J Pekka Nuorti; Robert F Breiman; Umesh D Parashar; Joel M Montgomery; Jacqueline E Tate

doi:10.1093/jpids/piv051

Intussusception Cases Among Children Admitted to Referral Hospitals in Kenya, 2002-2013: Implications for Monitoring Postlicensure Safety of Rotavirus Vaccines in Africa

J Pediatric Infect Dis Soc. 2016 Dec;5(4):465-469. doi: 10.1093/jpids/piv051. Epub 2015 Aug 25.

Authors

Richard Omore^{1

2}, Francis Osawa³, Janet Musia⁴, Brian Rha⁵, Amina Ismail⁶, Nicholas Mukaria Kiulia⁷, Fenny Moke¹, John Vulule¹, Anthony Mungai Wainaina⁸, John Tole⁹, Stanley Mugambi Machoki⁹, J Pekka Nuorti², Robert F Breiman^{10

11}, Umesh D Parashar⁵, Joel M Montgomery¹¹, Jacqueline E Tate⁵

Affiliations

¹ Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya.
² Department of Epidemiology, School of Health Sciences, University of Tampere, Finland.
³ Department of Surgery.
⁴ Department of Pediatrics and Child Health, School of Medicine, University of Nairobi, Kenya.
⁵ Division of Viral Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia.
⁶ Division of Disease Surveillance and Response, Ministry of Public Health and Sanitation, Nairobi, Kenya.
⁷ Enteric Viruses Research Group, Institute of Primate Research, Nairobi, Kenya.
⁸ Kenyatta National Hospital, Nairobi, Kenya.
⁹ Aga Khan University Hospital, Nairobi, Kenya.
¹⁰ Global Health Institute, Emory University, Atlanta, Georgia.
¹¹ Global Disease Detection Division, Kenya Office of the US Centers for Disease Control and Prevention, Nairobi, Kenya.

Abstract

To describe the epidemiology of intussusception before introduction of the rotavirus vaccine, we reviewed the records of 280 patients younger than 5 years who were hospitalized in Kenya between 2002 and 2013. The patients who died (18 [6.4%]) had sought care later after symptom onset than the patients who survived (median, 5 vs 3 days, respectively; P = .04). Seeking prompt care may improve therapeutic outcomes.

Keywords: Kenya; childhood mortality; intussusception; risk factors.

MeSH terms

Child, Preschool
Female
Humans
Infant
Infant, Newborn
Intussusception / epidemiology*
Intussusception / mortality
Kenya / epidemiology
Male
Patient Safety*
Product Surveillance, Postmarketing
Referral and Consultation
Retrospective Studies
Rotavirus Infections / epidemiology
Rotavirus Infections / prevention & control
Rotavirus Vaccines / administration & dosage*

Substances

Rotavirus Vaccines

Grants and funding

CC999999/ImCDC/Intramural CDC HHS/United States