Abstract
Unlike in pulmonary multidrug-resistant (MDR) tuberculosis, the clinical outcome of MDR tuberculous meningitis (TBM) in children, including extensively drug-resistant tuberculosis, is poor and management is challenging. We report the successful treatment of a case of extensively drug-resistant TBM in a 4-year-old girl, and we discuss implications for tuberculosis diagnosis and chemotherapy.
Keywords:
Western Cape; extensively drug-resistant; linezolid; treatment; tuberculous meningitis.
© The Author 2014. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: [email protected].
MeSH terms
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / adverse effects
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Antitubercular Agents / administration & dosage*
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Antitubercular Agents / adverse effects
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Chemical and Drug Induced Liver Injury / prevention & control
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Child, Preschool
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Drug Therapy, Combination / adverse effects
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Extensively Drug-Resistant Tuberculosis / diagnosis
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Extensively Drug-Resistant Tuberculosis / drug therapy*
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Female
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Humans
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Hypothyroidism / chemically induced
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Hypothyroidism / drug therapy
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Isoxazoles / administration & dosage
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Isoxazoles / adverse effects
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis*
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Oxazolidinones / administration & dosage
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Oxazolidinones / adverse effects
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Prednisolone / administration & dosage
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Prednisolone / adverse effects
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Treatment Outcome
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Tuberculosis, Meningeal / diagnosis
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Tuberculosis, Meningeal / drug therapy*
Substances
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Anti-Inflammatory Agents
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Antitubercular Agents
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Isoxazoles
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Oxazolidinones
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terizidone
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Prednisolone