Abstract
6,8,9-Trihydroxy-2-methyl-2H-naphtho[2,3-b]pyran-5,10-dion, a pigment of the sea urchin Echinothrix diadema, and six analogs were synthesized. The cytotoxic activity and contraceptive properties of the synthesized pyranonaphthazarins have been investigated using the sperm and eggs of the sea urchin Strongylocentrotus intermedius.
MeSH terms
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Animals
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Contraceptive Agents / chemical synthesis*
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Contraceptive Agents / toxicity
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Male
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Naphthoquinones / chemistry*
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Naphthoquinones / toxicity
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Ovum / drug effects
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Pigments, Biological / chemistry*
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Pigments, Biological / toxicity
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Pyrones / analysis
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Pyrones / chemical synthesis*
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Pyrones / toxicity
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Sea Urchins / chemistry*
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Spermatozoa / drug effects
Substances
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6,8,9-trihydroxy-2-methyl-2H-naphtho(2,3-b)pyran-5,10-dione
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Contraceptive Agents
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Naphthoquinones
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Pigments, Biological
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Pyrones