K13-Propeller Polymorphisms in Plasmodium falciparum Isolates from Patients in Mayotte in 2013 and 2014

Antimicrob Agents Chemother. 2015 Dec;59(12):7878-81. doi: 10.1128/AAC.01251-15. Epub 2015 Sep 28.

Abstract

Plasmodium falciparum isolates were collected from 29 malaria patients treated with artemether-lumefantrine in Mayotte in 2013 and 2014. Twenty-four cases (83%) consisted of imported malaria. Seventeen percent of the isolates presented mutations in one of the six K13-propeller blades (N490H, F495L, N554H/K, and E596G). A total of 23.8% of the isolates from the Union of Comoros showed K13-propeller polymorphisms. Three of the 18 isolates (16.7%) from Grande Comore showed polymorphisms (N490H, N554K, and E596G).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / pharmacology*
  • Artemether, Lumefantrine Drug Combination
  • Artemisinins / pharmacology*
  • Comoros / epidemiology
  • Drug Combinations
  • Drug Resistance / genetics
  • Ethanolamines / pharmacology*
  • Female
  • Fluorenes / pharmacology*
  • Humans
  • Malaria, Falciparum / drug therapy
  • Malaria, Falciparum / epidemiology*
  • Malaria, Falciparum / parasitology
  • Male
  • Mutation
  • Plasmodium falciparum / drug effects
  • Plasmodium falciparum / genetics*
  • Plasmodium falciparum / growth & development
  • Plasmodium falciparum / isolation & purification
  • Polymorphism, Genetic*
  • Protozoan Proteins / genetics*
  • Protozoan Proteins / metabolism
  • Retrospective Studies

Substances

  • Antimalarials
  • Artemether, Lumefantrine Drug Combination
  • Artemisinins
  • Drug Combinations
  • Ethanolamines
  • Fluorenes
  • Protozoan Proteins