Abstract
A novel ligand (FBTTBE) for Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) has been developed, which demonstrates not only superior catalytic efficiency but also the ease of removing toxic copper species. FBTTBE has also been successfully applied in the synthesis of radiometal-labeled peptide and antibody without observable transchelation with the non-radioactive Cu(i) catalyst.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alkynes / chemistry*
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Animals
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Antibodies / chemistry
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Azides / chemistry*
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Catalysis
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Cell Line, Tumor
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Copper / chemistry*
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Cyclization
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Cycloaddition Reaction*
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Fluorine / chemistry*
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Glioma / diagnosis*
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Humans
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Ligands
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Mice
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Mice, Nude
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Molecular Structure
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Neoplasms, Experimental / diagnosis
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry*
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Peptides / chemical synthesis
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Peptides / chemistry
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Positron-Emission Tomography
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Tomography, X-Ray Computed
Substances
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Alkynes
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Antibodies
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Azides
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Ligands
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Organometallic Compounds
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Peptides
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Fluorine
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Copper