Parallel Parkin: Cdc20 Takes a New Partner

Fernando Meza-Gutierrez; Frances V Hundley; David P Toczyski

doi:10.1016/j.molcel.2015.09.015

Parallel Parkin: Cdc20 Takes a New Partner

Mol Cell. 2015 Oct 1;60(1):3-4. doi: 10.1016/j.molcel.2015.09.015.

Authors

Fernando Meza-Gutierrez¹, Frances V Hundley¹, David P Toczyski²

Affiliations

¹ Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94143, USA.
² Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: [email protected].

Abstract

CDC20 and CDH1 are well-established substrate receptors for the Anaphase Promoting Complex/Cyclosome (APC/C). In this issue of Molecular Cell, Lee et al. (2015) show that these adaptors can also target cell cycle proteins for destruction through a second ubiquitin ligase, Parkin.

Publication types

Comment

MeSH terms

Animals
Cadherins / metabolism*
Cdc20 Proteins / metabolism*
Genomic Instability*
Humans
Mitosis*
Ubiquitin-Protein Ligases / genetics*
Ubiquitin-Protein Ligases / metabolism*

Substances

Cadherins
Cdc20 Proteins
Ubiquitin-Protein Ligases

Grants and funding

R35 GM118104/GM/NIGMS NIH HHS/United States