IGFBP3 and T1D: Systemic Factors in Colonic Stem Cell Function and Diabetic Enteropathy

Chia-Wei Cheng; Ömer H Yilmaz

doi:10.1016/j.stem.2015.09.008

IGFBP3 and T1D: Systemic Factors in Colonic Stem Cell Function and Diabetic Enteropathy

Cell Stem Cell. 2015 Oct 1;17(4):379-80. doi: 10.1016/j.stem.2015.09.008.

Authors

Chia-Wei Cheng¹, Ömer H Yilmaz²

Affiliations

¹ Koch Institute for Integrative Cancer Research at MIT and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
² Koch Institute for Integrative Cancer Research at MIT and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: [email protected].

PMID: 26431180
DOI: 10.1016/j.stem.2015.09.008

Abstract

Patients with type 1 diabetes (T1D) often experience gastrointestinal enteropathy (DE) of unclear etiology. Now in Cell Stem Cell, D'Addio et al. (2015) utilize organoid culture models to study the roles of stem cells in DE and show that circulating IGF/IGFBP3 controls colonic stem cell function during homeostasis and in T1D patients.

Publication types

Comment

MeSH terms

Animals
Colon / cytology*
Diabetes Complications / pathology*
Diabetes Mellitus, Experimental / pathology*
Humans
Insulin-Like Growth Factor Binding Protein 3 / blood*
Insulin-Like Growth Factor I / metabolism*
Stem Cells / physiology*

Substances

Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I

Abstract

Publication types

MeSH terms

Substances

Grants and funding