Abstract
We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6-20 times more selective than the parent drugs.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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DNA Topoisomerases, Type II / metabolism
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Nanoparticles / chemistry*
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Polymers / chemical synthesis
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Polymers / chemistry
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Polymers / pharmacology*
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STAT3 Transcription Factor / antagonists & inhibitors
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STAT3 Transcription Factor / metabolism
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Structure-Activity Relationship
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Triple Negative Breast Neoplasms / drug therapy*
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Triple Negative Breast Neoplasms / metabolism
Substances
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Antineoplastic Agents
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Polymers
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STAT3 Transcription Factor
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STAT3 protein, human
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DNA Topoisomerases, Type II