Abstract
Flaviviruses comprise approximately 70 closely related RNA viruses. These include several mosquito-borne pathogens, such as yellow fever virus (YFV), dengue virus (DENV), and Japanese encephalitis virus (JEV), which can cause significant human diseases and thus are of great medical importance. Vaccines against both YFV and JEV have been used successfully in humans for decades; however, the development of a DENV vaccine has encountered considerable obstacles. Here, we review the protective immune responses elicited by the vaccine against YFV to provide some insights into the development of a protective DENV vaccine.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antibodies, Viral / biosynthesis
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Cytokines / biosynthesis
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Cytokines / immunology
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Dendritic Cells / drug effects
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Dendritic Cells / immunology
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Dendritic Cells / virology
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Dengue / immunology
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Dengue / prevention & control*
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Dengue / virology
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Dengue Vaccines / administration & dosage*
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Dengue Vaccines / biosynthesis
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Dengue Vaccines / genetics
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Dengue Vaccines / immunology
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Dengue Virus / classification
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Dengue Virus / drug effects
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Dengue Virus / genetics
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Dengue Virus / immunology*
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Host-Pathogen Interactions
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Humans
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Immunity, Innate
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Lymphocytes / drug effects
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Lymphocytes / immunology
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Lymphocytes / virology
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Phylogeny
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RNA Helicases / genetics
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RNA Helicases / immunology
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Serine Endopeptidases / genetics
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Serine Endopeptidases / immunology
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Viral Nonstructural Proteins / genetics
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Viral Nonstructural Proteins / immunology
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Virus Replication / drug effects
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Yellow Fever / immunology
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Yellow Fever / prevention & control*
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Yellow Fever / virology
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Yellow Fever Vaccine / administration & dosage*
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Yellow Fever Vaccine / biosynthesis
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Yellow Fever Vaccine / genetics
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Yellow Fever Vaccine / immunology
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Yellow fever virus / classification
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Yellow fever virus / drug effects
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Yellow fever virus / genetics
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Yellow fever virus / immunology*
Substances
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Antibodies, Viral
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Cytokines
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Dengue Vaccines
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NS2B protein, flavivirus
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NS3 protein, flavivirus
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Viral Nonstructural Proteins
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Yellow Fever Vaccine
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Serine Endopeptidases
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RNA Helicases