Yeast: a microbe with macro-implications to antimicrobial drug discovery

Carl J Balibar; Terry Roemer

doi:10.1093/bfgp/elv038

Yeast: a microbe with macro-implications to antimicrobial drug discovery

Brief Funct Genomics. 2016 Mar;15(2):147-54. doi: 10.1093/bfgp/elv038. Epub 2015 Oct 5.

Authors

Carl J Balibar, Terry Roemer

PMID: 26443612
DOI: 10.1093/bfgp/elv038

Abstract

Paramount to any rational discovery of new antibiotics displaying novel mechanisms of action is a deep knowledge of the genetic basis of microbial growth, division and virulence. The bakers' yeast,Saccharomyces cerevisiae, illustrates the highest understanding of the genetic underpinnings of microbial life, and from this framework, a systems biology paradigm has evolved, begging to be emulated in antibacterial discovery. Here, we review landmark events in the history of yeast genomics that provide this new foundation for antibacterial drug discovery.

Keywords: Saccharomyces cerevisiae; antibacterial; antifungal; chemical biology; functional genomics; yeast.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Drug Discovery*
Genome, Bacterial
Genome, Fungal
Genomics*
Haploinsufficiency
Microbial Sensitivity Tests*
Saccharomyces cerevisiae / drug effects
Saccharomyces cerevisiae / genetics*