NAP1L1-MLLT10 is a rare recurrent translocation that is associated with HOXA activation and poor treatment response in T-cell acute lymphoblastic leukaemia

Br J Haematol. 2016 Aug;174(3):470-3. doi: 10.1111/bjh.13772. Epub 2015 Oct 12.

Jonathan Bond^{1

2}, Aurore Touzart^{1

2}, Agata Cieslak^{1

2}, Amélie Trinquand^{1

2}, Tony Marchand³, Martine Escoffre³, Audrey Contet⁴, Marc Muller⁵, Claudine Schmitt⁴, Thierry Fest³, Vahid Asnafi^{1

2}, Elizabeth Macintyre^{6

7}

¹ Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, Paris, France.
² Laboratory of Onco-Haematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.
³ Department of Haematology, University Hospital and INSERM UMR 917, Rennes 1 University, Rennes, France.
⁴ Department of Paediatric Haematology, University Hospital, Nancy, France.
⁵ Genetics Laboratory, University Hospital, Nancy, France.
⁶ Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, Paris, France. [email protected].
⁷ Laboratory of Onco-Haematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France. [email protected].

No abstract available

Keywords: HOXA; acute leukaemia; biology; clinical aspects; leukaemia cytogenetics.

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