Propofol effects on cerebellar long-term depression

Kwan Young Lee; Young Im Kim; Se Hoon Kim; Hyung Seo Park; Youn Joon Park; Myung Sook Ha; Yunju Jin; Dong Kwan Kim

doi:10.1016/j.neulet.2015.09.037

Propofol effects on cerebellar long-term depression

Neurosci Lett. 2015 Nov 16:609:18-22. doi: 10.1016/j.neulet.2015.09.037. Epub 2015 Oct 9.

Authors

Kwan Young Lee¹, Young Im Kim², Se Hoon Kim³, Hyung Seo Park⁴, Youn Joon Park⁵, Myung Sook Ha⁶, Yunju Jin⁷, Dong Kwan Kim⁸

Affiliations

¹ Department of Physiology, Konyang University, College of Medicine, Daejeon, South Korea; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Electronic address: [email protected].
² Department of Physiology, Konyang University, College of Medicine, Daejeon, South Korea; Department of Anesthesiology, Yeosu Chonnam Hospital, Yeosu, South Korea. Electronic address: [email protected].
³ Department of Physiology, Konyang University, College of Medicine, Daejeon, South Korea. Electronic address: [email protected].
⁴ Department of Physiology, Konyang University, College of Medicine, Daejeon, South Korea. Electronic address: [email protected].
⁵ Department of Pediatric Surgery, Dankook University, College of Medicine, Cheonan, South Korea. Electronic address: [email protected].
⁶ Department of Ophthalmology, Konyang University Hospital, Daejeon, South Korea; Myunggok Medical Research Institute, Konyang University College of Medicine, Daejeon, South Korea. Electronic address: [email protected].
⁷ Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. Electronic address: [email protected].
⁸ Department of Physiology, Konyang University, College of Medicine, Daejeon, South Korea; Myunggok Medical Research Institute, Konyang University College of Medicine, Daejeon, South Korea. Electronic address: [email protected].

PMID: 26455962
DOI: 10.1016/j.neulet.2015.09.037

Abstract

Propofol is an intravenously administered anesthetic that induces γ-aminobutyric acid-mediated inhibition in the central nervous system. It has been implicated in prolonged movement disorders. Since the cerebellum is important for motor coordination and learning, we investigated the potential effects of propofol on cerebellar circuitry. Using the whole-cell patch-clamp technique in Wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (PF) to Purkinje cell (PC) synapses (PF-LTD). Also, propofol reduced metabotropic glutamate receptor 1 (mGluR1)-mediated and group I mGluR agonist-induced slow currents in PCs. These results suggest that the propofol-induced PF-LTD impairment may be related to an alteration in mGluR1 signaling, which is essential to motor learning.

Keywords: Cerebellum; Long-term depression; Metabotropic glutamate receptor 1; Parallel fiber; Propofol; Purkinje cell.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anesthetics, Intravenous / pharmacology*
Animals
Cerebellum / drug effects*
Cerebellum / physiology
In Vitro Techniques
Long-Term Synaptic Depression / drug effects*
Propofol / pharmacology*
Purkinje Cells / drug effects
Purkinje Cells / physiology
Rats, Wistar
Receptors, Metabotropic Glutamate / metabolism

Substances

Anesthetics, Intravenous
Receptors, Metabotropic Glutamate
metabotropic glutamate receptor type 1
Propofol