Thymus Polypeptide Preparation Tactivin Restores Learning and Memory in Thymectomied Rats

A V Novoseletskaya; N M Kiseleva; I V Zimina; O V Bystrova; O V Belova; A N Inozemtsev; V Ya Arion; V I Sergienko

doi:10.1007/s10517-015-3030-6

Thymus Polypeptide Preparation Tactivin Restores Learning and Memory in Thymectomied Rats

Bull Exp Biol Med. 2015 Sep;159(5):623-5. doi: 10.1007/s10517-015-3030-6. Epub 2015 Oct 13.

Authors

A V Novoseletskaya¹, N M Kiseleva^{2

3}, I V Zimina³, O V Bystrova³, O V Belova³, A N Inozemtsev⁴, V Ya Arion³, V I Sergienko³

Affiliations

¹ Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov, Moscow State University, Moscow, Russia. [email protected].
² Department of Pharmacology,Pediatric Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
³ Laboratory of Molecular Immunology and Biochemistry, Research Institute of Physicochemical Medicine, Federal Medical-and-Biological Agency of Russia, Moscow, Russia.
⁴ Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov, Moscow State University, Moscow, Russia.

PMID: 26459479
DOI: 10.1007/s10517-015-3030-6

Abstract

We studied the effects of tactivin and splenic polypeptides on learning and memory of thymectomized animals. In 3-week rats, thymectomy blocked active avoidance conditioning. Injections of tactivin (0.5 mg/kg) during 1 month after surgery restored learning capacity; splenic polypeptides were ineffective.

Keywords: learning; memory; thymectomy; thymus.

MeSH terms

Animals
Avoidance Learning / drug effects*
Avoidance Learning / physiology
Conditioning, Classical / physiology
Memory / drug effects*
Memory / physiology
Nootropic Agents / isolation & purification
Nootropic Agents / pharmacology*
Organ Specificity
Peptides / isolation & purification
Peptides / pharmacology*
Rats
Rats, Wistar
Spleen / chemistry
Thymectomy*
Thymus Extracts / isolation & purification
Thymus Extracts / pharmacology*
Thymus Gland / chemistry*
Thymus Gland / physiology
Thymus Gland / surgery

Substances

Nootropic Agents
Peptides
Thymus Extracts
T-activin