Tigecycline Lock Therapy for Catheter-Related Bloodstream Infection Caused by KPC-Producing Klebsiella pneumoniae in Two Pediatric Hematological Patients

Sergio Foresti; Stefano Di Bella; Attilio Rovelli; Alessandra Sala; Marta Verna; Luca Bisi; Carla Nisii; Andrea Gori

doi:10.1128/AAC.01855-15

Tigecycline Lock Therapy for Catheter-Related Bloodstream Infection Caused by KPC-Producing Klebsiella pneumoniae in Two Pediatric Hematological Patients

Antimicrob Agents Chemother. 2015 Dec;59(12):7919-20. doi: 10.1128/AAC.01855-15. Epub 2015 Oct 12.

Authors

Sergio Foresti¹, Stefano Di Bella², Attilio Rovelli³, Alessandra Sala³, Marta Verna³, Luca Bisi¹, Carla Nisii⁴, Andrea Gori¹

Affiliations

¹ Infectious Diseases Division, San Gerardo de' Tintori Hospital, Monza, Italy.
² Infectious Diseases Division, San Gerardo de' Tintori Hospital, Monza, Italy [email protected].
³ BMT Unit, Pediatric Department, San Gerardo de' Tintori Hospital, Monza, Italy.
⁴ Laboratory of Microbiology, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy.

Abstract

Catheter-related bacteremias carry high mortality rates in hematological patients. When a multidrug-resistant microorganism is involved, the catheter should ideally be removed; however, this approach is not always possible. Tigecycline lock therapy was used in two pediatric oncohematological patients with intravascular catheter-related infection due to KPC-producing Klebsiella pneumoniae. The catheter was salvaged in both cases, and the patients were later discharged. Our experience suggests the usefulness of this approach in treating this type of infection.

Publication types

Case Reports

MeSH terms

Adolescent
Anemia, Aplastic / complications
Anemia, Aplastic / drug therapy
Anemia, Aplastic / immunology
Anemia, Aplastic / pathology
Anti-Bacterial Agents / therapeutic use*
Antineoplastic Agents / therapeutic use
Bacteremia / complications
Bacteremia / drug therapy*
Bacteremia / immunology
Bacteremia / pathology
Catheter-Related Infections / complications
Catheter-Related Infections / drug therapy*
Catheter-Related Infections / immunology
Catheter-Related Infections / pathology
Central Venous Catheters
Drug Administration Schedule
Female
Humans
Immunosuppressive Agents / therapeutic use
Infant
Klebsiella Infections / complications
Klebsiella Infections / drug therapy*
Klebsiella Infections / immunology
Klebsiella Infections / pathology
Klebsiella pneumoniae / drug effects
Klebsiella pneumoniae / growth & development
Klebsiella pneumoniae / pathogenicity
Minocycline / analogs & derivatives*
Minocycline / therapeutic use
Tigecycline
Treatment Outcome

Substances

Anti-Bacterial Agents
Antineoplastic Agents
Immunosuppressive Agents
Tigecycline
Minocycline