Survival and Local Recurrence After Video-Assisted Thoracoscopic Lung Metastasectomy

World J Surg. 2016 Feb;40(2):373-9. doi: 10.1007/s00268-015-3254-7.

Abstract

Background: Pulmonary metastasectomy is increasingly performed in selected patients by video-assisted thoracic surgery (VATS) on the base of thin-slice high-resolution CT-Scan (HRCT). This study determines the overall survival and ipsilateral recurrence rate and of patients undergoing after VATS lung metastasectomy.

Patients and method: Retrospective single institution study of all patients who underwent VATS pulmonary metastasectomy on the base of HRCT with curative intent between 2005 and 2014.

Results: Seventy-seven patients (41 males, 36 females) underwent VATS pulmonary metastasectomy for solitary (n = 63) or multiple (n = 14) lung metastases in the context of colorectal carcinoma (n = 26), sarcoma (n = 17), melanoma (n = 16), or other primaries (n = 18). Nine patients had bilateral lung metastases and underwent synchronous (n = 4) or sequential (n = 5) VATS resections. Preoperative CT-guided hook wire localization of the lesions was performed in 65 patients (84 %). The postoperative mortality and morbidity rates were 0 and 5.2 %, respectively. During a mean follow-up time of 24 months (range 1–120 months), tumor progression occurred in 46 patients. Twenty-three patients (30 %) had pulmonary recurrence only, of them, eight patients (10 %) in the operated lungs. Seven of eight patients with recurrence in the operated lungs underwent a second metastasectomy by VATS (n = 5) or thoracotomy (n = 2). The overall 5-year survival rate was 54 % and without difference between patients without tumor recurrence and those with pulmonary recurrence treated by re-metastasectomy.

Conclusion: Ipsilateral recurrence remains low after VATS pulmonary metastasectomy guided by preoperative HRCT and can be efficiently treated by re-metastasectomy.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Colorectal Neoplasms / pathology*
  • Disease Progression
  • Female
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / secondary
  • Lung Neoplasms / surgery*
  • Male
  • Melanoma / secondary*
  • Metastasectomy
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / secondary
  • Neoplasm Recurrence, Local / surgery*
  • Reoperation
  • Retrospective Studies
  • Sarcoma / secondary*
  • Survival Rate
  • Thoracic Surgery, Video-Assisted*
  • Thoracotomy
  • Tomography, X-Ray Computed
  • Young Adult