Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex

Benjamin M Ellingson; Yoko Hirata; Akira Yogi; Elena Karavaeva; Kevin Leu; Davis C Woodworth; Robert J Harris; Dieter R Enzmann; Joyce Y Wu; Gary W Mathern; Noriko Salamon

doi:10.1177/0883073815609151

Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex

J Child Neurol. 2016 Apr;31(5):636-45. doi: 10.1177/0883073815609151. Epub 2015 Oct 15.

Authors

Affiliations

¹ Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA, USA [email protected].
² Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA Department of Neurosurgery, Toho University Ohashi Medical Center, Tokyo, Japan.
³ Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nakagami-gun, Okinawa, Japan.
⁴ Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
⁵ Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA, USA.
⁶ Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA Department of Biomedical Physics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
⁷ Department of Pediatrics, Division of Pediatric Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
⁸ Departments of Neurosurgery and Psychiatry and Biobehavioral Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

PMID: 26472749
DOI: 10.1177/0883073815609151

Abstract

Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.

Keywords: analysis of differential involvement; epilepsy; population maps; seizures; topographic mapping; tuberous sclerosis complex.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Brain / diagnostic imaging*
Brain / pathology
Brain Mapping*
Child
Child, Preschool
Cohort Studies
Epilepsy / diagnostic imaging*
Epilepsy / etiology*
Epilepsy / pathology
Female
Humans
Image Processing, Computer-Assisted
Infant
Magnetic Resonance Imaging
Male
Tuberous Sclerosis / complications*
Young Adult

Abstract

Publication types

MeSH terms

Grants and funding