Fertility in childhood cancer survivors following cranial irradiation for primary central nervous system and skull base tumors

Tamara Z Vern-Gross; Julie A Bradley; Ronny L Rotondo; Daniel J Indelicato

doi:10.1016/j.radonc.2015.10.001

Fertility in childhood cancer survivors following cranial irradiation for primary central nervous system and skull base tumors

Radiother Oncol. 2015 Nov;117(2):195-205. doi: 10.1016/j.radonc.2015.10.001. Epub 2015 Oct 20.

Authors

Tamara Z Vern-Gross¹, Julie A Bradley¹, Ronny L Rotondo¹, Daniel J Indelicato²

Affiliations

¹ Department of Radiation Oncology, University of Florida, Jacksonville, FL, United States.
² Department of Radiation Oncology, University of Florida, Jacksonville, FL, United States. Electronic address: [email protected].

PMID: 26475251
DOI: 10.1016/j.radonc.2015.10.001

Abstract

Recent advances in pediatric cancer treatment have improved disease control and survival outcomes for childhood cancers survivors, including those treated for primary central nervous system and skull base malignancies. Future research in this population will focus on identifying risk factors for infertility, novel screening techniques and recommendations, and quality-of-life outcomes improvement. The purpose of this review is to define the infertility complications observed in pediatric cancer survivors who receive cranial irradiation for central nervous system and skull base malignancies.

Keywords: Fertility; Pediatric; Radiation therapy.

Publication types

Review

MeSH terms

Central Nervous System Neoplasms / epidemiology
Central Nervous System Neoplasms / radiotherapy*
Child
Cranial Irradiation / adverse effects*
Fertility / radiation effects*
Gonadotropins / physiology
Gonads / radiation effects
Humans
Infertility / epidemiology
Infertility / etiology
Risk Assessment / methods
Skull Base Neoplasms / epidemiology
Skull Base Neoplasms / radiotherapy*
Survivors

Substances

Gonadotropins