L-671,329, a new antifungal agent. I. Fermentation and isolation

R E Schwartz; R A Giacobbe; J A Bland; R L Monaghan

doi:10.7164/antibiotics.42.163

L-671,329, a new antifungal agent. I. Fermentation and isolation

J Antibiot (Tokyo). 1989 Feb;42(2):163-7. doi: 10.7164/antibiotics.42.163.

Authors

R E Schwartz¹, R A Giacobbe, J A Bland, R L Monaghan

Affiliation

¹ Merck Sharp & Dohme Research Laboratories, Rahway, N.J. 07065-0900.

PMID: 2647703
DOI: 10.7164/antibiotics.42.163

Abstract

In screening for new antifungal agents from fungi, a new lipopeptide antifungal agent, L-671,329, similar to echinocandin B, has been isolated from Zalerion arboricola. Studies indicate that L-671,329 is produced under both solid and liquid fermentation conditions.

MeSH terms

Anti-Bacterial Agents*
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Candida albicans / drug effects
Candida albicans / growth & development
Chromatography, High Pressure Liquid
Echinocandins
Fermentation
Peptides*
Peptides, Cyclic / isolation & purification
Peptides, Cyclic / pharmacology

Substances

Anti-Bacterial Agents
Antifungal Agents
Echinocandins
Peptides
Peptides, Cyclic
pneumocandin A(0)