Exercise, Autophagy, and Apoptosis

Exercise is a form of physiological stress which is known to induce an adaptational response. It is proposed that both apoptosis and autophagy are processes which are necessary for adaptation to exercise. Apoptosis and autophagy are induced during exercise to limit tissue damage, restore tissue integrity, terminate inflammatory responses, or induce direct signals for adaptation. Apoptosis is induced by specific mediators like reactive oxygen species, cytokines, and hormones. Autophagic pathways are activated by altered proteins/organelles with the aim to conserve and recycle the cellular resources. In this case, the cell is flooded with damaged molecules, the repairing mechanisms are overtaxed, and apoptosis is induced. In conclusion, autophagy seems to be necessary for adaptation by providing locally the conditions for muscle plasticity and apoptosis systemically by mobilizing progenitor cells.