Abstract
Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.
MeSH terms
-
Animals
-
Caspases / metabolism
-
Humans
-
Inflammation / metabolism
-
Intracellular Signaling Peptides and Proteins
-
Lipopolysaccharides / immunology*
-
Mice
-
Mice, Knockout
-
Neoplasm Proteins / genetics
-
Neoplasm Proteins / metabolism
-
Phosphate-Binding Proteins
-
Pyroptosis*
Substances
-
GSDMD protein, human
-
Gsdma protein, mouse
-
Intracellular Signaling Peptides and Proteins
-
Lipopolysaccharides
-
Neoplasm Proteins
-
Phosphate-Binding Proteins
-
Caspases