The ins and outs of selective kinase inhibitor development

Nat Chem Biol. 2015 Nov;11(11):818-21. doi: 10.1038/nchembio.1938.

Authors

Susanne Müller¹, Apirat Chaikuad¹, Nathanael S Gray², Stefan Knapp³

Affiliations

¹ Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK.
² Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
³ Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Oxford, UK and the Institute for Pharmaceutical Chemistry and Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe-University, Frankurt am Main, Germany.

PMID: 26485069
DOI: 10.1038/nchembio.1938

No abstract available

MeSH terms

Allosteric Site
Catalytic Domain
Crystallography, X-Ray
Drug Approval
Drug Design*
Drug Discovery*
Humans
Protein Conformation
Protein Kinase Inhibitors / chemical synthesis
Protein Kinase Inhibitors / chemistry*
Protein Kinases / chemistry*
Quantitative Structure-Activity Relationship
Small Molecule Libraries / chemical synthesis
Small Molecule Libraries / chemistry*
United States
United States Food and Drug Administration

Substances

Protein Kinase Inhibitors
Small Molecule Libraries
Protein Kinases

Grants and funding

106169/Wellcome Trust/United Kingdom