First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States

J Clin Microbiol. 2016 Jan;54(1):168-71. doi: 10.1128/JCM.02478-15. Epub 2015 Oct 21.

Abstract

Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur in patients without previous azole exposure have been reported in Europe, Asia, the Middle East, Africa, and Australia. Here, we report the detection of both the TR34 L98H and TR46 Y121F T289A mutations in confirmed A. fumigatus isolates collected in institutions in the United States. These mutations, other mutations known to cause azole resistance, and azole MICs are reported here.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Aspergillosis / microbiology
  • Aspergillus fumigatus / drug effects
  • Aspergillus fumigatus / enzymology*
  • Aspergillus fumigatus / genetics*
  • Aspergillus fumigatus / isolation & purification
  • Azoles / pharmacology*
  • Drug Resistance, Fungal*
  • Humans
  • Microbial Sensitivity Tests
  • Mutation, Missense*
  • Sterol 14-Demethylase / genetics*
  • United States

Substances

  • Antifungal Agents
  • Azoles
  • Sterol 14-Demethylase

Grants and funding

This project was supported in part by a San Antonio Life Sciences Institute (SALSI) Clusters in Research Excellence Award to Nathan P. Wiederhold.