Comparison of analgesic requirements after liver transplantation and cholecystectomy

Mayo Clin Proc. 1989 Mar;64(3):356-9. doi: 10.1016/s0025-6196(12)65257-4.

Abstract

In a prospective study of 10 patients who underwent liver transplantation and 10 patients who underwent cholecystectomy, we analyzed the postoperative analgesic requirements and the resultant plasma morphine concentrations. Analgesia was more intense, with less medication, and the plasma morphine concentration was significantly lower in the liver transplant group than in the cholecystectomy group. This finding is most likely attributable to endogenous factors rather than to altered morphine pharmacokinetics.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Body Weight
  • Cholecystectomy*
  • Female
  • Fentanyl / administration & dosage
  • Fentanyl / blood
  • Humans
  • Kidney / physiology
  • Liver Transplantation*
  • Male
  • Middle Aged
  • Morphine / administration & dosage*
  • Morphine / blood
  • Morphine / pharmacokinetics
  • Pain, Postoperative / drug therapy*
  • Pain, Postoperative / metabolism
  • Prospective Studies

Substances

  • Morphine
  • Fentanyl