Pathogen Resistance Mediated by IL-22 Signaling at the Epithelial-Microbiota Interface

J Mol Biol. 2015 Nov 20;427(23):3676-82. doi: 10.1016/j.jmb.2015.10.013. Epub 2015 Oct 21.

Abstract

Intestinal colonization resistance to bacterial pathogens is generally associated, among other factors, with mucosal homeostasis that preserves the integrity of the intestinal barrier. Mucosal homeostasis depends on physical and molecular interactions between three components: the resident microbiota, the epithelial layer and the local immune system. The cytokine IL-22 helps to orchestrate this three-way interaction. IL-22 is produced by immune cells present beneath the epithelium and is induced by bacteria present in the intestine. IL-22 stimulates the epithelial cells via the IL-22RA1-IL-10R2 receptor complex inducing changes in the expression of genes involved in the maintenance of epithelial barrier integrity, with a variety of functions in pathogen resistance such as mucus layer modifications and hydration, tight junction fortification and the production of a broad range of bactericidal compounds. These mechanisms of pathogen resistance, in turn, affect the microbiota composition and create an environment that excludes pathogens. Here we highlight the role of IL-22 as key mediator in the give-and-take relationship between the microbiota and the host that impacts pathogen resistance.

Keywords: IL-22 signaling; epithelium; intestinal microbiota; mucus; pathogen resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Infections / metabolism
  • Bacterial Infections / microbiology
  • Epithelial Cells / metabolism
  • Epithelial Cells / microbiology*
  • Gastrointestinal Microbiome / physiology*
  • Host-Pathogen Interactions / physiology*
  • Humans
  • Immunity, Mucosal
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / microbiology*
  • Receptors, Interleukin / metabolism*
  • Signal Transduction

Substances

  • IL22RA2 protein, human
  • Receptors, Interleukin