NONINVASIVE GRADING OF RADIATION RETINOPATHY: The Use of Optical Coherence Tomography Angiography

Retina. 2015 Nov;35(11):2400-10. doi: 10.1097/IAE.0000000000000844.

Abstract

Purpose: Previous studies have shown that spectral domain optical coherence tomography can diagnose radiation retinopathy (RR) before ophthalmoscopic findings. Recently, optical coherence tomography angiography (OCT-A) has been helpful in seeing vascular findings undetected by spectral domain optical coherence tomography. The authors wish to demonstrate the OCT-A grading at varying levels of RR.

Methods: The OCT-A, spectral domain optical coherence tomography, and ophthalmoscopic findings on 7 patients from December 2014 to March 2015 with varying levels of RR are demonstrated.

Results: Findings on OCT-A could be demonstrated before spectral domain optical coherence tomography findings. Patients can be graded on a scale of increasing severity from 0 to 5, based on positive or negative clinical findings of RR between OCT-A. Optical coherence tomography increased central macular thickness, optical coherence tomography evident cysts, and ophthalmoscopy (Grade 0: -,-,-,-; Grade 1: +,-,-,-; Grade 2: +,+,-,-; Grade 3: +,+,+,-; Grade 4: ++,+,+,+; Grade 5: unreadable,++,++,+).

Conclusion: The use of OCT-A allows for earlier detection of RR; thus, existing grading systems should be modified to include OCT-A.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Brachytherapy / adverse effects*
  • Choroid Neoplasms / radiotherapy
  • Female
  • Fluorescein Angiography*
  • Humans
  • Iodine Radioisotopes
  • Male
  • Melanoma / radiotherapy
  • Middle Aged
  • Radiation Injuries / classification*
  • Radiation Injuries / etiology
  • Radiation Injuries / pathology
  • Retina / radiation effects*
  • Retinal Diseases / classification*
  • Retinal Diseases / etiology
  • Retinal Diseases / pathology
  • Tomography, Optical Coherence*

Substances

  • Iodine Radioisotopes