The use of wide diameter implants (WDI) have had a great success, particularly in posterior jaws, because WDI can ensure an increased bone-implant contact, better withstanding occlusal forces and creating a wider platform for prosthesis. The aim of this study is to perform a study on 450 WDI to evaluate their survival rate. In the period between January 2008 and December 2013, 877 patients (498 females and 379 males) were operated at the BDD private Practice Clinic (Milan, Italy). The mean post-surgical follow-up was 30±17 months (max min, 84 1). Four hundred and fifty WDI (EDIERRE Implant System SpA, Genoa, Italy) were included in the present study, 326 (72.4%) 4.5 mm and 124 (27.6%) 5 mm. All patients underwent the same surgical protocol and agreed to participate in a post-operative check-up program. SPSS program was used for statistical analysis. Survival rate (SVR) was 97.3% since only 12 fixtures were lost from a total of 450 implants. Cross-tabulation between failures and immediate loading had a statistically significant value (p= 0.009) in respect to delayed loading. There were 8 failures out of 128 immediate loaded implants in respect to 4 failures out of 315 delayed loaded fixtures. WDI are reliable devices for oral rehabilitation with high SVR.