Abstract
Naltrexone-bupropion is a recently approved drug combination for chronic weight management. In this article, we discuss the rationale for its use as a combination followed by a comprehensive review of safety and efficacy data from major preclinical, phase II and III clinical trials.
Keywords:
Naltrexone; bupropion; obesity; type 2 diabetes; weight loss.
MeSH terms
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Animals
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Anti-Obesity Agents / administration & dosage
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Anti-Obesity Agents / adverse effects
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Anti-Obesity Agents / therapeutic use*
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Bupropion / administration & dosage
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Bupropion / adverse effects
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Bupropion / therapeutic use*
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Delayed-Action Preparations
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Drug Approval
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Drug Combinations
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Humans
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Naltrexone / administration & dosage
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Naltrexone / adverse effects
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Naltrexone / therapeutic use*
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Obesity / drug therapy*
Substances
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Anti-Obesity Agents
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Delayed-Action Preparations
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Drug Combinations
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bupropion hydrochloride, naltrexone hydrochoride drug combination
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Bupropion
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Naltrexone