Prevalence and clinical outcome of hepatic haemangioma with specific reference to the risk of rupture: A large retrospective cross-sectional study

Dig Liver Dis. 2016 Mar;48(3):309-14. doi: 10.1016/j.dld.2015.09.016. Epub 2015 Oct 3.

Abstract

Background: Prevalence and incidence of hepatic haemangioma are estimated from autopsy series only. Although benign and generally asymptomatic, hepatic haemangioma can cause serious complications.

Aims: The aim of the study was to assess the prevalence of hepatic haemangioma and to attempt to quantify the risk of major complications such as spontaneous rupture.

Methods: We retrospectively analyzed the radiology database of a Regional University Hospital over a 7-year period: the radiological records of 83,181 patients who had an abdominal computed tomography or magnetic resonance scan were reviewed. Diagnoses made at imaging were reviewed and related to clinical course.

Results: Hepatic haemangioma was diagnosed in 2071 patients (2.5% prevalence). In 226 patients (10.9%), haemangioma had diameter of 4 cm or more (giant haemangioma). The risk of bleeding was assessed on patients without concomitant malignancies. Spontaneous bleeding occurred in 5/1067 patients (0.47%). All 5 patients had giant haemangioma: 4 had exophytic lesions and presented with haemoperitoneum; 1 with centrally located tumour experienced intrahepatic bleeding.

Conclusion: Giant haemangiomas have a low but relevant risk of rupture (3.2% in this series), particularly when peripherally located and exophytic. Surgery might be considered in these cases.

Keywords: Hepatic haemangioma; Risk of rupture; Treatment.

MeSH terms

  • Adult
  • Aged
  • Cross-Sectional Studies
  • Databases, Factual
  • Female
  • Hemangioma / diagnostic imaging
  • Hemangioma / epidemiology*
  • Humans
  • Incidental Findings
  • Italy / epidemiology
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / epidemiology*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Prevalence
  • Retrospective Studies
  • Rupture, Spontaneous / epidemiology
  • Tomography, X-Ray Computed