Chemotherapy Induced Acute Pericarditis in a Child

J Coll Physicians Surg Pak. 2015 Oct:25 Suppl 2:S81-3. doi: 10.2015/JCPSP.S81S83.

Abstract

A9 years boy diagnosed with nasopharyngeal carcinoma was started on chemotherapy protocol including 5-fluorouracil. After 90 hours of 5-fluorouracil infusion, he developed severe retrosternal chest pain. Electrocardiography showed signs of acute pericarditis and was managed with ibuprofen and 5-fluorouracil was discontinued. The 5-fluorouracil rarely causes cardiac complications such as angina pectoris and pericarditis in adult patients. We report acute myopericarditis in a child caused by 5-fluorouracil, which is a very rare complication of 5-fluorouracil in pediatric age group.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Biopsy
  • Carcinoma
  • Chest Pain / diagnosis*
  • Chest Pain / drug therapy
  • Chest Pain / etiology
  • Child
  • Electrocardiography
  • Fluorouracil / administration & dosage
  • Fluorouracil / adverse effects*
  • Humans
  • Ibuprofen / therapeutic use
  • Infusion Pumps
  • Magnetic Resonance Imaging
  • Male
  • Nasopharyngeal Carcinoma
  • Nasopharyngeal Neoplasms / diagnosis
  • Nasopharyngeal Neoplasms / drug therapy*
  • Pericarditis / chemically induced*
  • Pericarditis / drug therapy
  • Tachycardia, Sinus
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Fluorouracil
  • Ibuprofen