An improved synthesis of [26-(2)H3]castasterone

Vladimir N Zhabinskii; Olga V Gulyakevich; Peter V Kurman; Polina S Shabunya; Svetlana A Fatykhava; Vladimir A Khripach

doi:10.1002/jlcr.3353

An improved synthesis of [26-(2)H3]castasterone

J Labelled Comp Radiopharm. 2015 Nov-Dec;58(13-14):469-72. doi: 10.1002/jlcr.3353. Epub 2015 Nov 2.

Authors

Vladimir N Zhabinskii¹, Olga V Gulyakevich¹, Peter V Kurman¹, Polina S Shabunya¹, Svetlana A Fatykhava¹, Vladimir A Khripach¹

Affiliation

¹ Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich str., 5/2, 220141, Minsk, Belarus.

PMID: 26526489
DOI: 10.1002/jlcr.3353

Abstract

Commercially available epicastasterone has been employed as a starting material for the preparation of [26-(2)H3 ]castasterone. The chemical synthesis has been realized in 13 chemical steps and 4.6% total yield. The target compound is intended to be used as internal standard for the quantitative analysis of brassinosteroids.

Keywords: brassinosteroids; castasterone; deuterium; epicastasterone; synthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cholestanols / chemical synthesis*
Cholestanols / chemistry
Radiopharmaceuticals / chemical synthesis*
Radiopharmaceuticals / chemistry
Tritium / chemistry*

Substances

Cholestanols
Radiopharmaceuticals
Tritium
castasterone