Efficient and facile synthesis of novel stable monodeuterium labeled ractopamine

Feifei Su; Fulong Wu; He Tang; Zhonghua Wang; Fanhong Wu

doi:10.1002/jlcr.3355

Efficient and facile synthesis of novel stable monodeuterium labeled ractopamine

J Labelled Comp Radiopharm. 2015 Nov-Dec;58(13-14):479-82. doi: 10.1002/jlcr.3355. Epub 2015 Nov 2.

Authors

Feifei Su¹, Fulong Wu¹, He Tang¹, Zhonghua Wang^{1

2}, Fanhong Wu¹

Affiliations

¹ School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, China.
² Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.

PMID: 26526706
DOI: 10.1002/jlcr.3355

Abstract

A novel synthetic route to stable deuterium labeled ractopamine was disclosed with 6.49% total yield and 97.7% isotopic abundance. Its structure and the isotope-abundance were confirmed according to (1)H-NMR and high-resolution mass spectrometry.

Keywords: deuterium labeling; drug standards; ractopamine; β-adrenergic agonists.

MeSH terms

Deuterium / chemistry*
Phenethylamines / chemical synthesis*
Phenethylamines / chemistry

Substances

Phenethylamines
ractopamine
Deuterium