Induction of the metastatic phenotype by transfection of the nuclear oncogene p53: increases in cytoplasmic diacylglycerol levels and reduction in class I major histocompatibility antigen expression are not sufficient to explain the changes in metastatic capacities

J Cancer Res Clin Oncol. 1989;115(2):145-7. doi: 10.1007/BF00397914.

Abstract

Transfection of the oncogene encoding the nuclear protein p53 into a low-metastatic mouse carcinoma cell line resulted in enhanced metastatic capabilities in clones that showed increased p53 protein expression [Pohl J, Goldfinger N, Radler-Pohl A, Rotter V, Schirrmacher V (1988) Mol Cell Biol 8:2078-2081]. This effect seemed neither to be due to increase in cytoplasmic diacylglycerol levels nor to reduced cell-surface expression of class I major histocompatibility antigens.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cell Line
  • Cell Membrane / analysis
  • Clone Cells
  • Cytoplasm / metabolism
  • Diglycerides / metabolism*
  • Genes, ras*
  • Glycerides / metabolism*
  • H-2 Antigens / analysis
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / metabolism*
  • Mice
  • Neoplasm Metastasis / genetics*
  • Neoplasm Proteins / genetics*
  • Phenotype
  • Phosphoproteins / genetics*
  • Transfection*
  • Tumor Suppressor Protein p53
  • Urinary Bladder Neoplasms / genetics*
  • Urinary Bladder Neoplasms / immunology

Substances

  • Diglycerides
  • Glycerides
  • H-2 Antigens
  • Histocompatibility Antigens Class I
  • Neoplasm Proteins
  • Phosphoproteins
  • Tumor Suppressor Protein p53