Complications after surgery for metastatic humeral lesions

J Shoulder Elbow Surg. 2016 Feb;25(2):207-15. doi: 10.1016/j.jse.2015.08.009. Epub 2015 Nov 5.

Abstract

Background: Knowledge of surgical outcome and its predictors helps inform patients and aids in surgical decision-making. We aimed to assess the outcome-reoperation and systemic complication rate-of surgery for humeral metastases, myeloma, or lymphoma. Our null hypothesis was that there are no factors associated with these outcomes.

Methods: We included 295 consecutive patients in this retrospective study: 134 (45%) proximal, 131 (44%) diaphyseal, and 30 (10%) distal impending or pathologic fractures. Proximal lesions were treated by intramedullary nailing (43%, n = 57), prosthesis (34%, n = 46), plate-screw fixation (22%, n = 30), and a combination (n = 1). Diaphyseal lesions were treated by intramedullary nailing (69%, n = 91), plate-screw fixation (30%, n = 39), and a combination (n = 1). Distal lesions were treated by plate-screw fixation (97%, n = 29) and intramedullary nailing (3.3%, n = 1).

Results: We found 25 (8.5%) reoperations, and 17 (5.8%) patients had 18 systemic complications: pneumonia (3.7%, n = 11), pulmonary embolism (1.3%, n = 4), sepsis (0.68%, n = 2), and fat embolism (0.34%, n = 1). No factors were independently associated with reoperation. Logistic regression analysis demonstrated that favorable cancer status (i.e., a higher modified Bauer score: odds ratio, 0.48; 95% confidence interval, 0.29-0.80; P = .005) was independently associated with a decreased systemic complication rate.

Conclusion: Poor cancer status was an independent predictor of postoperative systemic complications. This could help inform the patient and anticipate postoperative problems.

Keywords: Humerus; carcinoma; lymphoma; myeloma; operative; surgery metastases.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bone Neoplasms / complications
  • Bone Neoplasms / mortality
  • Bone Neoplasms / secondary
  • Bone Neoplasms / surgery*
  • Embolism, Fat / etiology
  • Female
  • Follow-Up Studies
  • Fracture Fixation, Internal*
  • Fractures, Spontaneous / etiology
  • Fractures, Spontaneous / surgery*
  • Humans
  • Humeral Fractures / etiology
  • Humeral Fractures / surgery*
  • Male
  • Middle Aged
  • Pneumonia / etiology
  • Postoperative Complications / etiology*
  • Pulmonary Embolism / etiology
  • Reoperation / statistics & numerical data
  • Retrospective Studies