Hyperbaric index in the primary prevention of hypertensive complications in high-risk pregnancy

Nefrologia. 2015 Nov-Dec;35(6):572-7. doi: 10.1016/j.nefro.2015.10.001. Epub 2015 Nov 5.
[Article in English, Spanish]

Abstract

Introduction: Preeclampsia (PE) is a major cause of fetal morbidity and mortality. In the Western World, PE affects 2-7% of pregnancies and is responsible for 50,000 deaths annually. Early detection is a priority as it can change the clinical course, but there are no biomarkers or instrumental methods with high sensitivity and specificity. Only the hyperbaric index has a sensitivity and specificity of 99% for early identification of pregnant women at risk of developing PE, but its use is not widespread.

Objective: To assess the usefulness of the hyperbaric index in the primary prevention of hypertensive pregnancy complications in a public healthcare area.

Material and methods: This is a retrospective study of pregnancies that occurred in our area during the period 2007-2012 (N=11,784). The diagnosis was established by the hyperbaric index and pregnant women at risk were treated with ASA at night.

Results: In pregnant patients referred to the nephrology clinic (38.2%), diagnosed as high-risk for PE, and treated with 100mg ASA/night (from week 17), the incidence of PE episodes was reduced by 96.94.

Keywords: Embarazo; Hipertensión; Hyperbaric index; Hypertension; Pregnancy; Índice hiperbárico.

MeSH terms

  • Adult
  • Aspirin / administration & dosage
  • Aspirin / therapeutic use
  • Blood Pressure Monitoring, Ambulatory
  • Blood Pressure*
  • Drug Administration Schedule
  • Early Diagnosis
  • Female
  • Humans
  • Hypertension, Pregnancy-Induced / diagnosis
  • Hypertension, Pregnancy-Induced / physiopathology
  • Hypertension, Pregnancy-Induced / prevention & control*
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Aggregation Inhibitors / therapeutic use
  • Pre-Eclampsia / prevention & control*
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy, High-Risk / physiology*
  • Retrospective Studies
  • Sensitivity and Specificity

Substances

  • Platelet Aggregation Inhibitors
  • Aspirin