[Recovery of Cushing syndrome revealing McCune-Albright syndrome]

S Halioui-Louhaichi; Y Dridi; O Azzabi; I Selmi; I Fetni; N Siala; A Maherzi

doi:10.1016/j.arcped.2015.09.018

[Recovery of Cushing syndrome revealing McCune-Albright syndrome]

Arch Pediatr. 2016 Jan;23(1):61-5. doi: 10.1016/j.arcped.2015.09.018. Epub 2015 Nov 6.

[Article in French]

Authors

S Halioui-Louhaichi¹, Y Dridi², O Azzabi², I Selmi², I Fetni², N Siala², A Maherzi²

Affiliations

¹ Service de pédiatrie, hôpital Mongi Slim La Marsa, faculté de médecine de Tunis, université de Tunis El Manar, La Marsa, Tunisie. Electronic address: [email protected].
² Service de pédiatrie, hôpital Mongi Slim La Marsa, faculté de médecine de Tunis, université de Tunis El Manar, La Marsa, Tunisie.

PMID: 26552628
DOI: 10.1016/j.arcped.2015.09.018

Abstract

Cushing syndrome (CS) is a rare feature of McCune-Albright syndrome. Treatments consist of bilateral adrenalectomy followed by lifelong glucocorticoid and mineralocorticoid treatment. However, cases of spontaneous remission of CS have been reported in the literature. We report a case of McCune-Albright syndrome with CS treated with metyrapone for 30 months with prolonged remission after a 12-year follow-up. Adrenalectomy may be avoided in some cases of CS caused by McCune-Albright syndrome. Metyrapone could be a good alternative to surgical treatment.

Publication types

Case Reports

MeSH terms

Child
Cushing Syndrome / drug therapy*
Cushing Syndrome / etiology
Enzyme Inhibitors / therapeutic use*
Female
Fibrous Dysplasia, Polyostotic / complications*
Follow-Up Studies
Humans
Metyrapone / therapeutic use*
Remission Induction

Substances

Enzyme Inhibitors
Metyrapone