The N- and C-terminal ends of RPGR can bind to PDE6δ

EMBO Rep. 2015 Dec;16(12):1583-5. doi: 10.15252/embr.201541404. Epub 2015 Nov 9.

Abstract

This study shows that the prenylated C‐terminus of RPGR can bind to PDE6δ with high affinity, suggesting two distinct binding sites of the RPGR/PDE6δ complex. The serine residue at the −3 position relative to the prenylated cysteine seems to play a key role in defining the selectivity of PDE6δ towards ciliary prenylated cargo.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • ADP-Ribosylation Factors / chemistry*
  • Animals
  • Cyclic Nucleotide Phosphodiesterases, Type 6 / chemistry*
  • Eye Proteins / chemistry*
  • GTP-Binding Proteins / chemistry*
  • Humans

Substances

  • Eye Proteins
  • Cyclic Nucleotide Phosphodiesterases, Type 6
  • GTP-Binding Proteins
  • ADP-Ribosylation Factors